Apply over the area about to care: Face, neck, cleavage and hands. Apply with a soft massage. It can be used with cosmetic equipment like electrophoresis, iontophoresis, transdermal mesotherapy by electroporation, radiofrequency or others. Use sunscreen after treatment, as by leaving the horny layer thinner, the skin is more susceptible to damage, and sun exposure with no protection can cause the appearance of spots.